I think if it was a successful hijacking we would know by now. The hijackers would of made demands by now if they kept hostages, or taken credit for it and named whatever offended them causing them to do it.
Hijackers usually have a motive, and historically the motives typically involved some form of monetary exchange or demands for political asylum. You don't generally hijack a plane unless you either want to go somewhere or you want something in return.
That doesn't mean it's impossible for a hijacking to be done quietly, with no demands, but it's further complicated by the fact that the aircraft has to land somewhere. It's also somewhat difficult to hide a plane as large as a 777, much less find an airport to land it where it'll go unnoticed. This increases the likelihood that if it were a hijacking, it was probably similar to PSA flight 1771 [1] and more inline with a murder/suicide than a ransom.
Although, imagine the possibilities terrorists could use a 777 for. Load it with explosives, biological weapons, radioactive materials... It's enough to make a politician want to ban flying altogether. Let's hope they don't find my comment.
Regardless, I'm not especially comfortable wagering a bet on the cause of MA370's disappearance. My initial instinct was to presume foulplay or an in-flight fire. Now I'm not so sure.
If the aircraft isn't found, I suspect this might become the mystery of the century.