I've been working remotely for 2 years in Barcelona with the main office being in NYC. The 6 hours I have for myself before people wake up in NYC are incredibly focused and productive and I have 3 hours of overlap for meetings and catchup which seems to be working out quite well.

One important thing is to reach out and chat with people on a daily basis to avoid feeling isolated and also of course visit in person once in a while to have a bit of face time.