There is an API so I believe your suggestion ought to be possible. Just to play devil's advocate though; wouldn't people overestimate Wolfram's capabilities and expect the bot to be able to answer all sorts of difficult questions that it can't grok, particularly about ongoing political/cultural events which seems to be the lifeblood of Twitter, thereby making the service look kind of lame and useless..?

I'll do whatever gets the most votes but it seems this thread was forsaken. Would have been nice to see more discussion/refinery!