I haven't used pngquant in years (the last time I used it was for supporting PNG transparency in IE6), but I happened to use the excellent linked tool ImageAlpha on an HTML5/Flash game we are in the middle of shipping and managed to cut 1.2MB out of 7+MB in assets from it. That's pretty impressive.
The interesting thing is that the blur filter gave zero benefit, but the "median cut" pngquant to palletize the images gave some pretty impressive gains.
The interesting thing is that the blur filter gave zero benefit, but the "median cut" pngquant to palletize the images gave some pretty impressive gains.