I've also successfully implemented Zakas' [1] approach after watching his presentation "Scalable Javascript Application Architecture" [2] and abandoning Backbone.Aura [3]. Aura theoretically implements this, but in practice we found that it made some assumptions that were incompatible with our needs. Consequently, we rolled our own implementation.
(which was also posted by politician) was very useful in explaining the theory. I also made some changes to it, but offhand I can't remember what they were. I think it was to do with the separation of starting vs initialising modules (parts of a page).
