No. Others have pointed out a few, but I can't let Pyramid go unmentioned. The ideal framework; gives you what you need to bind your code to the web, without being obtrusive. You write pure Python with whatever components you choose or with the sensible defaults provided and use Pyramid's config systems to bundle it all together into a cohesive "website". It's awesome, and the only framework I've used like that. Truly simple (not "simple" like Rails, Django, or other frameworks where simple means "a million abstractions, assumptions, and exclusive language expansions that practically turn it into a derived DSL"), fast, and smooth.