Not only do I get slowdowns and some videos don't load at all at times, but I also get a notification that explains that the reason is using adblockers.
Here I am, totally given up on adblockers, and no way I’m paying for premium, but jesus christ the amount of ads I get, sometimes seems to be one every minute, making most videos unwatchable.
Though it’s mostly good for my addiction since it makes me use youtube less.
I had the same problem. Make sure you're running the latest version of uBlock Origin. By that I mean you should explicitly check for updates and install the latest version. That fixed it for me.
I've disabled adblock/vpn and can watch maybe 1-2 videos before the video player starts blacking out on each one. Only restarting firefox "resets" it and I haven't been able to find a reason for this happening. Time for yt-dlp I guess