Two domain focused examples:
Blender material node: I could imagine certain material nodes to be highly annoying to script (or even represented differently than nodes), even something relatively simple like this
https://i.imgur.com/kETcJYE.png (nodes),
https://i.imgur.com/eddAhcv.png (final render)
Fusion comp node: On the other hand, this seems like a lot of blocks for this simple image:
https://i.imgur.com/ftfHngt.png
(Cool thing about Fusion is that any node can be copy/pasted to notepad as text and vise-versa)
Note: I'am neither Blender nor Fusion expert.