If you are interested in novel keyboard layouts, there are many 2-dimensional chromatic layouts where transposition is isomorphic (i.e. playing in a different key only requires changing where you start). In one notable example, all major and minor triads can be played with a single finger[1], because 5ths and major/minor thirds are always adjacent.
I gave it a shot but found it difficult to unlearn a decade of traditional piano training. Also, unlike typing in Dvorak, you can't just use software to change the layouts of existing instruments. That said, if anyone knows where to find a high-quality piano with a chromatic layout, I'd love play it!
The Lumatone is a high quality isomorphic keyboard. There's software to control the layouts, and you can use layouts other people have created: https://en.xen.wiki/w/Category:Lumatone_mappings . I'll warn you though that the keyboard costs around 4000 USD, and it's around a 2 month wait for the company to build it and ship it after the order.
Thanks, the Janko layout was another one I was trying to remember; I was thrown because the images on the Janko wikipedia page are of the original Janko, and I had seen the Janko layout on the Japanese keyboards (e.g. the Chromatone and the Wholetone) which use hexagonal keys so look quite different.
1: http://www.shapeofmusic.com/note-pattern.php