I don’t work in your area, but my observation is: you seem to have a strong opinion about the validity of certain experimental work. Moreover, your opinion does not appear to be broadly shared by your fellow reviewers, and (here I make a second presumption) also by many experimental scientists submitting work to these venues. I don’t know if your opinion is valid or incorrect - that is incidental to the discussion - but I sure wish that reviewers would agree on basic standards in advance, rather than surprising scientists with disagreements about them after researchers have done enormous amounts of work and spent public funds. The situation you’re describing (basically, having a debate about standards in the wrong place) seems very harmful.