I did a quick google since I’ve never heard of misfolded albumin in the serum before and didn’t find anything.. are you asking from any prior research or discussions? Just from my knowledge I’d be surprised if there’s any amount of misfolded protein in the blood stream - every protein molecule in the blood stream needs to be actively salvaged (in your kidneys and macrophages) from degradation and this salvation is provided through their binding to receptors. If albumin is misfolded it should be cleared out quite fast. Note this is why antibody based drugs are more popular now - you get month long half lives for free.
Were those discussions about proteins in general misfolding or specifically serum albumin? This is an important distinction, many conversations I've overheard from those not in a bio field seem to gloss over vital details
