Even if the applications don't care, there's still the (Docker) container, which cares very much, and which seems to be the vehicle of choice to package and deliver many cloud-based applications today. Being able to actually run the exact same containers on your dev machine which are going to be running on the servers later is definitely a big plus.
Docker has had multiarch support for a while and most of the containers I’ve looked at support both. That’s not to say this won’t be a concern but it’s at the level of “check a box in CI” to solve and between Apple and Amazon there’ll be quite a few users doing that.
