For me, space is under the natural resting place of my right thumb. Enter on the left. And then the closer on each is backspace on right, delete on left. As well as layer toggling. It didn't take me too long to get used to the locations of most keys, but tweaked it over time. My weird one is I have `~ where caps lock would traditionally be. I use it a lot for code blocks in slack and things like that. And it really screws me up on another keyboard now where its not there. And then the bottom 4 on each hand, I really don't use much, volume toggles, win key and stuff like that. I need to figure out what else to do with them.