I created a website for toddlers in HTML5 +JS http://microangels.in . The website works great in safari, firefox & chrome but when I tried to use phonegap the page would not show up. Debugging in phonegap is a pain and I did not find much help in documentation, mailing list or IRC . I ended up using the android webview + Jquery mobile and the app works great I will need to look at the iOS next. So I would say that go with html5 and the native webview and it should be easy to add in the parts that need to be written in Obj-c or java easily instead of trying to figure out the frameworks