You obviously won't die from not watching Game of Thrones.
However, depending on your circle of friends and acquaintances, you might be excluded from social interactions. This can range from not getting occasional references, to not being able to participate in many conversations (during "peak" Game of Thrones a couple of years ago, they were a major and frequent topic in many circles) and hence being side-lined, to even being semi-ostracised ("Why should they hang out with this loser who doesn't even watch Game of Thrones?"). Obviously you could claim that you should get other/better friends, but that's not really realistic, especially if you're already on the border of social isolation.
This will have negative effects on your well-being and even your health (loneliness is a major health risk, on par with obesity and smoking).[0]
However, depending on your circle of friends and acquaintances, you might be excluded from social interactions. This can range from not getting occasional references, to not being able to participate in many conversations (during "peak" Game of Thrones a couple of years ago, they were a major and frequent topic in many circles) and hence being side-lined, to even being semi-ostracised ("Why should they hang out with this loser who doesn't even watch Game of Thrones?"). Obviously you could claim that you should get other/better friends, but that's not really realistic, especially if you're already on the border of social isolation.
This will have negative effects on your well-being and even your health (loneliness is a major health risk, on par with obesity and smoking).[0]
[0] https://www.webmd.com/balance/news/20180504/loneliness-rival...