Amphetamine is primarily absorbed through the plasma membranes and not DAT since it’s lipid soluble.
Dopamine does not and thus relies on DAT. By inhibiting DAT (as both amphetamine and Modafinil do), you increase extracellular dopamine.
Next, DAT does not “transport amphetamine around the brain”. It only transports it from the post synaptic cleft into the cell.
Also Modafinil is a much weaker DAT inhibitor than amphetamine itself as far as we know.
Lastly, drugs don’t “antagonize” other drugs. That word is a specific term used for the action on the receptor level.
The dopaminergic effects of Modafinil aren’t well known and are thought to be mild. It’s simply misinformation to claim that modafinil was somehow blocking the effects of amphetamine on the dopamine receptors.
You get the same result in a short span of time, heck you may even get a reliable error bound.
Where this falls apart is that error accumulates over time and not just for one heap of sand but for many such heaps of sand that also interact with other heaps of sand.
Predicting weather for the next hour is trivial. Aviation runs on the fact that you can forecast fairly accurately into the next hour most of the time.
The difficulty scales superlinearly over time due to the error accumulation over predictions
I wanted, but when I press ENTER, it asks to register... I click cancel and notice PRICING page. I click on it and again it asks for login. That is NOT how one onboards users.
In my opinion, Automatic1111 is more of a development tool to experiment with different pipelines on your local GPU, or an internal tool serving a few users.
OneDiffusion project aims to solve a very different problem, which is bringing a SD pipeline to serve production traffic and scale in the cloud. For example, configuring a large diffusion model to run on multi-GPU: https://huggingface.co/blog/deploy-deepfloydif-using-bentoml
I find your statement about the Edison quote disingenuous. I did some reading about the origin of the quote and it isn’t as cut and dry as you seem to claim.
Also, the quote is meaningful because Edison said it, not because the quote has merit in and of itself.
It’s inspiring because someone of Edison’s acclaim attributed his success to hard work. Anyone else could have said it and it wouldn’t have been a meaningful quote because they weren’t as successful as him.
Note that my statement doesn’t presuppose that he was successful solely due to his own efforts or that he isn’t a fraud etc. But rather that the significance of the quote relies on his perception as being successful in the public eye.
Edison and his company are a complex topic.
Many have pointed in the past that they have been discredited for the participation and Thomas name appeared are sole inventor.
Although they were employees of his company, and the patent would belong to Edison he (seemingly) made sure to disappear with any registries of their participation.
Of course, this could be words of the envious, but it is notable that more recent events such the system that led the creation of IBM Watson had their creator/inventor kicked out of IBM and his name erased from company registries. They only admitted their participation many years afterwards.
Edison sabotaged Tela's efforts by doing public safety demonstration, only to steal his ideas later down the line.
It is hard for me to trust a man who burnt an elephant
You may be relieved to know that Edison never killed an elephant. The elephant's owners killed it and held a barbaric public event. Employees of the Edison Film Company filmed the event, as a sort of early newsreel (one among many around that time), which is how Edison's name got associated with it. But Edison himself was completely uninvolved, and his company did nothing to bring the event about. The notion that this was some sort of public demonstration against DC current is a complete myth. For one thing, it took place a decade after the war of the currents.
Not to undermine your clarifying the truth, it's worth pointing out some of the confusion about that episode probably stems from some of what transpired during the war of the currents. The reason people falsely remembered it as a demonstration against AC is probably in part because it resembled things done in demonstration against AC:
