>Do we really need insurance to cover $100/mo meds?
For people making how much? Low income people are jumping through the hoops to get SNAP. $100 for them is a lot, and which they might just not have. And for insurance it would be cheaper long-run than dealing with diabetes, etc.
Anyway, why a such "submarine" attack on the $100 GLP-1 sources and why now? Well, one way of thinking would be that Trump RX just went online and there, thanks to the well known Trump's care about people's needs, the GLP-1 is $350, so one has to remove the $100 competitors.
It’s not a submarine attack at all. If anything I bet you these compounders are surprised they haven’t been shut down already for blatantly violating the law.
It’s a case of trying to get so many consumers buying that regulators are scared to touch you due to blowback. Much like Uber did.
>What do you think is happening with the efficiency gains?
may it happen that the efficiency gains decrease demand and thus postpone investment into and development of new and better energy sources? If one couldn't get by just by bringing 20 trucks with gas turbines, may be he would have invested in fusion development :)
> may it happen that the efficiency gains decrease demand
What mechanism would make this happen?
Demand could decrease if AI became worse, but efficiency doesn't make AI worse - it actually makes possible at all to run bigger, better models (see the other comment with a link to Jevon's paradox), which increase, not decrease demand (more powerful models may have new capabilities that people want to use)
Alternatively, AI demand could decrease through political pressure (either anti-AI sentiment takes a foothold on the public, and/or government regulation strangle demand on the sector like it did for eg. on tobacco industry). But another way to reap the benefits of more efficient AI datacenters is to make it a talking point on how AI environmental impacts can be mitigated, which could curb anti-AI sentiment.
Either way, those possibilities don't decrease demand for AI - they are either neutral, or increase demand instead.
>Scott Aaronson was born on May 21st, 1981. He will be 30 in 2011. The conference could follow a theme of: “hurry to think together with Scott Aaronson while he is still in his 20s and not yet a pitiful over-the-hill geezer in his 30s.” This offers another nice opportunity for celebration.
may be somebody would train a model on the Epstein and his associates emails/etc. which would allow to research the workings of the such psychopaths' minds
"in March 2025, a
political advocacy group contacted two members of SSA’s DOGE Team with a request to analyze
state voter rolls that the advocacy group had acquired. The advocacy group’s stated aim was to
find evidence of voter fraud and to overturn election results in certain States. "
Its main mode of operation is fish-net-style catching brown people on the streets and making them sign voluntary deportation. That allows to bypass any court orders and any requirements of the law (like hearing, lawyer, etc).
Edit: to the commenter below:
>I care because my children are approaching the workforce and I want their opportunities to open up to them
do you really want your children to work in strawberry fields in CA in 100+ degrees weather? That is the opportunities which mostly get open when you remove the migrants, legal or illegal, that ICE is targeting.
I'm a brown immigrant, the process to get into the US legally was long. I trust US institutions to have good intent, but like all institutions they fail at times. The mandate is to remove 25 million illegal migrants. I reject the hostile posture that people are taking based on negatively biased information, which in my view, further reassures me they are acting in Americans' best interest. I care because my children are approaching the workforce and I want their opportunities to open up to them, unlike I've witnessed in the tech industry where unscrupulous businesses have happily replaced American workers with labor that is desperate. You can't convince me that the negative bias toward ICE isn't in large part, funded and astroturfed by elements in the business lobby that don't care about unemployed citizens and residents, and further drafted by those who have jobs so can afford to not care.
Deporting 25 million people using a terrorist militia is mass ethnic cleansing. Period. Has nothing to do with the job market, it is a basic historical reality.
If you want job opportunities to open up to your children, perhaps you should invest in parenting that teaches them good values (like hard work and good attitude), education and sense of agency in place of hoping some government agency will kidnap and deport enough immigrants (many of which are legal, like you btw) for market to offer enough demand for them.
The above point about „quality” of jobs „taken” by the immigrants is also very valid…
You believe jobs are being taken and handed to deserving illegal immigrants because they have a better work ethic. I believe they are because investors are seeking ever greater returns no matter the cost to other others or even the long term sustainability of those very returns. This is the basis of our different positions.
Because the rules of this land are the end result of waves of developments, over millennia, hard won through the observation of the cause and effect of policy on societies. I trust the effectiveness of American law on the basis of the success of the American Experiment. This very success is the draw that led me to leave my homeland and family and come here. So I'll go with American Law and legal system, rather than follow some reactionary duct-taped law some guy commenting on the internet says we should do.
>They literally are going around thinking they don't need judicial warrants.
Noem at the Senate hearing : "Well, habeas corpus is a constitutional right that the president has to be able to remove people from this country, and suspend their right to ..."
ICE got additional $80B over next 4 years in addition to the standard appropriations resulting in $28B budget for example in this year. That definitely gonna buy a lot of “market research”.
To whom? To the country losing people or to the country getting people? Like, what is the cost of Elon Musk immigration? And who bears that cost? And who enjoys the benefits of it?
>Also don't try to pull it out even when its halfway out of your body or it will snap and die and give you a super nasty infection as it decays inside of you.
Pardon probably stupid question, yet i'm wondering why (under local or general anesthesia of course) it isn't possible to "drain snake" the remainder of the worm and to clean/disinfect the worm channel that way. After all we insert similar flexible stuff into blood vessels from say thigh all the way up to the heart.
As you might expect from the description -- largely passed on via contaminated water -- the guinea worm is mostly present in areas of extreme poverty. Even if such a treatment were feasible, it would be inaccessible to most of the relevant population.
Not a stupid question at all, it's actually quite logical thinking. Here's why it's not that straightforward:
The worm is extremely fragile. Guinea worms can be up to a meter long but are very thin and delicate. When you pull too quickly or forcefully, the worm breaks. This is the central problem — it's not like a catheter or guide wire, which are engineered to have tensile strength. The worm's body is essentially a thin biological tube filled with millions of larvae.
Breaking it is the real danger. When the worm ruptures, it releases those larvae and bodily fluids into the surrounding tissue, triggering a severe inflammatory reaction, secondary bacterial infection, and sometimes abscess formation or sepsis. This is far worse than the worm itself. So the traditional slow winding onto a stick (a few centimeters per day) works with the worm's own gradual release from the tissue it's embedded in.
The path isn't a clean channel. Unlike a blood vessel, which is a defined, smooth lumen, the worm sits winding through subcutaneous connective tissue. It doesn't create a neat tunnel — it's loosely embedded and adhered to surrounding tissue along its length. There's no "pipe" to snake a tool through. A catheter in a blood vessel follows a pre-existing anatomical highway; here there's no such structure.
Surgical extraction is sometimes attempted, but it requires carefully dissecting along the entire worm's path without rupturing it — which is technically demanding, time-consuming, and requires facilities and skills that are often unavailable in the rural sub-Saharan communities where the disease occurs. For a worm that may wind through 30–60 cm of tissue, that's a significant operation for a condition that, while painful, is usually self-limiting.
The real solution turned out to be prevention. The Carter Center's eradication campaign brought cases from ~3.5 million per year in the 1980s to fewer than 15 per year now, almost entirely through water filtration and education — making the surgical question largely moot.
So in short: the worm isn't strong enough to pull, the path isn't clean enough to navigate, breaking it makes everything worse, and the settings where it occurs rarely have the surgical capacity for careful dissection.
>the worm sits winding through subcutaneous connective tissue. It doesn't create a neat tunnel — it's loosely embedded and adhered to surrounding tissue along its length.
that's bad. In my thinking i in particular missed that it may be winding instead of being more streamlined like say blood vessels/etc. Stuff of nightmares. Now i imagined a one winding in the grooves of the brain ...
in the 90-ies anyone could easily prototype with tools like Access (and all the other "4GL" tools which were similarly all the rage back then). That still didn't preclude companies from buying their major software from software vendors instead of doing it themselves.
In some sense having customer able to prototype what they want is a good thing. I did it myself as i was at the time on that side, and having a quick-whip-it tool was a good thing to quickly get some feature that was missing in the major software before that major software would add it (if at all).
(And if one remembers for example Crystal Reports - while for "reports", it and the likes were in many senses such quick-whip-it tools for a lot of such customization that was doable by the customer.)
So, after initial aftershock - "Ahhhh, we don't need software companies anymore!" - we'll get to the state with software companies still doing their thing just with a lot of AI as specialization is one of the main thing in modern economy and AI becomes most powerful tools of the trade. (and various AI components themselves will be part of software delivery, like say a very fine-tuned model (hosted or on-premise) specific to the customer and software - Clippy on steroids)
(Of course some companies wouldn't survive the transition just like some companies didn't survive the transitions to client/server, cloud, etc. while some new companies will emerge like Anthropic has today or Borland had at the time)
Access is not as dead as you might hope. The long tail of internal tools written with Access continues to shamble along. I had to figure out how to dump MDB files on Windows last year for just this reason. As an industry I think we often fail to grasp how much outsider art there is, in the form of internal departmental tools.
LLM coding is going to create a cambrian explosion of these tools. It’s going to be very interesting to see the remnants of this wave 30 years down the line.
One of the key questions here - will LLM coding decrease the proliferation of app-specific Excel files (by for example accelerating and simplifying Excel-to-webapp conversion) or would result in an opposite outcome by making feasible managing even orders of magnitude more of those disparate Excel files :)
I wouldn’t bet against cramming more and more business processes into Excel. The guy who was copying cells from one workbook to another yesterday, tomorrow can have a single mega-workbook with all the macros more or less deconflicted.
Internet routers, network cards, the computers, OS and various application software have no guardrails and is used for all the nefarious things. Why those companies aren't raided?
May be.
We do have codified in law definition of machine gun which clearly separates it from a block of lead. What codified in law definitions are used here to separate photoshop from Grok in the context of those deepfakes and CSAM?
Without such clear legal definitions going after Grok while not going after photoshop is just an act of political pressure.
They don’t provide a large platform for political speech.
This isn’t about AI or CSAM (Have we seen any other AI companies raided by governments for enabling creation of deepfakes, dangerous misinformation, illegal images, or for flagrant industrial-scale copyright infringement?)
No because most of those things aren't illegal and most of those companies have guard rails and because a prosecution requires a much higher standard of evidence than internet shitposting, and only X was stupid enough to make their illegal activity obvious.
For people making how much? Low income people are jumping through the hoops to get SNAP. $100 for them is a lot, and which they might just not have. And for insurance it would be cheaper long-run than dealing with diabetes, etc.
Anyway, why a such "submarine" attack on the $100 GLP-1 sources and why now? Well, one way of thinking would be that Trump RX just went online and there, thanks to the well known Trump's care about people's needs, the GLP-1 is $350, so one has to remove the $100 competitors.
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