From the article I read:

"A twelve-day-old infant cannot crawl. It cannot grab, and it cannot put something into its own mouth. “It also cannot swallow a Tylenol-3 pill,” Juurlink told me. “I don’t know what happened in that house, on that night, but I do know that someone gave this baby crushed Tylenol-3,” likely mixed in breast milk or formula. “That’s the only way these numbers make sense.”"

> Recently, Parvaz Madadi has undergone a painful process of revisiting her past work and memories. [...] She added that she had no confidence in the measurement of Rani’s breast-milk sample, because it had been handled by Koren’s lab.

There is a lot to process in this long article. The quote selected by 'steelbrain, concerning Koren's measurement occurs very, very early on, and much of the rest of the article is about contrasting Koren's early presentations of the material against others' testimony. It's worth reading the whole thing

To 'steelbrain: cherry-picking one single quote out of a nuanced article does the journalism here a dire disservice. It's okay for different people to have different beliefs and takeaways from the article. However, your own defense of the biological mechanism here is directly argued against in the "same article" you are admonishing others over reading. That is not conducive to a discussion in good faith.

Note that you and GP are talking about different values of "this." GP is talking about codeine, you're talking about morphine. The difference between the two is at the crux of this article.

It appears that they didn't really read the article before commenting.

The entire point, the damning evidence is that the child that died had codeine in his stomach, which he absolutely couldn't get from breast milk.

87 ng/mL.

Baby eats 30mL per hour. That's 2.6 micrograms of morphine.

Elimination half life in neonates of ~8 hours means 30 micrograms in system at equilibrium if constantly fed this and the baby absorbs all of it (takes 4-5 half lives to get to that) and pharmacokinetics are linear. In reality a neonate likely absorbs well under 1/3rd, so you'd expect under 10 micrograms in equilibrium.

25-50 micrograms/kilogram is normal dosing of morphine in a neonate when it is necessary, every 6 hours (resulting in a peak systemic concentration of ~60-120 ug/kg after repeated dosing).

Compare -- 60-120 ug/kg therapeutic dosing to 10 micrograms in the neonate's body (3-4 kilos, so 3 ug/kg??)

And then, you end up with acetaminophen and codeine in the neonate's stomach, with no morphine... Even though these do not end up in breast milk in significant quantities.

Neither the article nor the commenter you replied to has demonized the parents. Yes, both the evidence discussed in the article and the opinions of those interviewed indicate direct administration of a pharmaceutical; it is appropriate to discuss this. Nobody has pointed the finger at anyone; it would indeed be quite inappropriate for such a discussion to be held in this forum.

Furthermore, Koren lied about what the tests showed the stomach contents to be: he omitted codeine entirely. Codeine (per the article) would not be expected to be transferred by breastmilk -- it's metabolized into morphine to be effective.

There are some giant red flags with this situation. How awful.

As others have pointed out, emulating macOS is only a ToS violation if done on non-Apple hardware, and this tool supports macOS. There is a legitimate usecase of running macOS VM on macOS.

Sure, you could use some apple-provided emulation tool instead of QEMU but that's a matter of choice, not a violation of ToS.

Disclaimer: I'm not a lawyer. This is not legal advice.

It might not block everything to the degree of uBlock Origin, but it does block network requests.

is there a way to make more innovation in this area and maybe an extension or two developed adding more perms etc or forking Orion or the know-how behind it and replicating it could finally allow PWA on apple iphones?

and neither of them allow any sort of extensions on top

Orion is the only one I think which still supports firefox or chrome extensions as well. I am sure that it can support PWA or already does, not sure, someone should probably test it out.

Theoretically if you can modify the engine enough to run firefox/chrome extensions on it when firefox/chrome themselves on Iphone can't but somehow Orion can, I don't see a reason why nobody's else doing it but combined with some really really good pwa support as well?

I would love to discuss about it and how Orion works then.

My question to you is, how is Orion possible to get firefox/chromium extensions working in webkit then, Because I know that Orion's core itself is built on top of webkit but I am wondering what other additions they did to make it possible to have firefox extensions as an example on the Ios

Can you please walk me through how this is possible? I see no other being able to do such a thing. Like how do they make it work then while the engine bundles in Ios.

I also want to ask if possible is that since I can just go to firefox mozilla addon store and get any extension and use it in Orion. Isn't this sort of really similar to an app store itself with 0 restrictions considering that firefox extensions are very unrestricted usually and similar to PWA (not sure)

This is already possible with Orion so I am wondering why more discoveries are not being done in this space. I would love seeing an open source alternative to Orion as well for Iphone perhaps.

Thank you for telling me that browsers work at an operating system level in Ios but can you please tell me how Orion's then able to do such stuff? And can certain more discoveries be made on that front regarding PWA support , extension support similar to orion etc. as well then?

Is there no way that something can be done for PWA abilities? What's stopping PWA on ios, I don't really follow? I would love it if you can clear up my confusion regarding it.

What am I missing?

(In other words: curl is using Rust, just not a specific Rust HTTP/1 backend anymore. But the site doesn’t limit its scope to just that backend.)

Writing module bundlers in Javascript had diminishing returns from multi threading because of the overhead of serializing and deserializing ASTs.

I wonder how far something like this would push the ceiling. Would love to see some benchmarks of this thing hauling ASTs around.

Talk to the engineers to figure out how much it would cost to capture that natgas. Set the fine for flaring natural gas to be that, + $10,000 or so per day.

Voila! Suddenly it's economical to capture that natgas.

That's why we need to make the worse method more expensive, so price sensitive buyers don't go for that one.