The Vitamin E / NAC relationship are interesting. As far as I understand, there needs to be a balance of anti-oxidants (C, E, Selenium, etc). To make it worse there are so many formulations of Vitamin E you can buy (tocopherols, tocotrienols, etc). Sometimes its hard to tell from the studies what forms exactly were being used.
You may also find this interesting:
"NRF2 activation is a predictor of poor clinical outcomes in lung cancer. Given the widespread use of NRF2-inducing compounds such as resveratrol and sulforaphane, these findings raise important concerns about their safety in individuals at risk for or living with cancer."
I agree wholeheartedly. The app is unusable and unstable. I had to delete collections from the web because they were getting corrupted in the app.
One thing I notice is that it simply does not render many code snippets well, especially when using the "page" (vs "continuous" scrolling). I don't get the impression they are doing QA on rendering quality. Not only external publishers, but O'Reilly books themselves! I also had a lot of problems reading Manning books in their app.
Rendering e-books properly is a pretty big table-stake thing.
"Affinity Partners, the private equity firm led by Jared Kushner, is part of Paramount's hostile takeover bid for Warner Bros Discovery, according to a regulatory filing."
This is what happens in markets without a functional regulatory body - when the regulator turns into a market participant. It’s closer to a jungle than anything else.
Thank you, I had no idea how this was politically related, and honestly cannot keep track of all the corruption these days anyways. How does anyone? This is pretty much a genuine question.
"The Biden-era immigration surge delivered millions of new arrivals seeking work; foreign-owned fleets recruited aggressively—higher pay than at home, no experience needed, free “housing” in the sleeper berth."
I was talking to a retired trucker recently. They described a situation where one driver would get the CDL, but shared the cab with 2-3 others (no CDL, maybe family or friends). They would all rotate driving, so at any given time there was a chance the driver actually had no CDL.
For the first time ever, since I got my first mac in 2009, I have not updated to the latest OS when I had the choice, because of this. I'm hoping the next major OS version rectifies the situation.
I would definitely try this if the vehicles in Phoenix ran cleaner. The old ones have such bad smelling exhaust and you are always breathing it because of the semi-open cab.
I look at the PM2.5 data for my city every day, and at this point (Nov) in the winter season, the only acceptable time to exercise is between 2PM-4PM after vertical mixing kicked in. Outside that duration, particulates are elevated after morning rush our, after evening rush hour, or during overnight inversion trapping evening rush hour + wood burning smoke until the next morning rush hour.
This is one the main reasons why I would prefer working remote, it is hard to utilize this time well (for exercise) if you are in the office.
At least with PM you can wear a mask, although I am still searching for the best one that works during intense exercise.
Also wanted to point out
"Trump EPA moves to abandon rule that sets tough standards for deadly soot pollution"
Thanks, that's one of the masks I use! Unlike the GVS SPM587 it has a quick release thing so you can get to your hydration for water and microplastics :/
With respect to the supplement industry, it could be improved quite a lot if there was large scale testing of purity and potency, by the government presumably. There should be fines if whats in the bottle is not what the label says.
I subscribe to Consumer Labs but they simply don't have the resources to even scratch the surface. The chocolate I eat was approved by CL in 2019, I doubt the results are even valid.
But I doubt RFK would be interested in any of this.
The term "supplement" has been stretched too far, agreed. It is up to the consumer to do the research, but how many consumers have the background to do it? "Third party testing" is supposedly done by some manufacturers, but not by all. But the side effects and interactions of some pharma products should raise eyebrows too.
Honestly, the idea that supplements are harmless... Is harmful.
The number of supplements that boost or deplete things like CYP3A4 (commonly known as don't eat grapefruit on BP meds) is responsible for an unknown number of unintentional overdose deaths- and healthcare is such that frequently doctors don't realize it at all.
You may also find this interesting:
"NRF2 activation is a predictor of poor clinical outcomes in lung cancer. Given the widespread use of NRF2-inducing compounds such as resveratrol and sulforaphane, these findings raise important concerns about their safety in individuals at risk for or living with cancer."
https://link.springer.com/article/10.1007/s11357-025-01736-0
Many people eat high-sulforaphane containing foods for health benefits.
And finally from last week https://newatlas.com/diet-nutrition/vitamin-c-air-pollution-...
This was about 1000mg / day for humans.
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