Yes, this is very important. But one should not forget also the avg. hospitalization time (which will go down once we have clear procedures for treating COVID in different stage)
The active dose is nowhere near the lethal dose. It is however close to the dose where you could see some minor damage to the liver. It causes problems because people are addicted to opioid drugs that are typically combined with acetaminophen, not because they are loading up on acetaminophen itself.
Paracetamol is dangerous in overdose, and the therapeutic dose is pretty close to the overdose amount. The therapeutic index is approx 10.
Compare that to morphine, which has a therapeutic index of about 70.
(although the therapeutic index is tricky to use because of dose response curves)
We know that paracetamol is commonly used in both accidental and deliberate overdose. And this is true in countries that don't have the opioid crisis, and it was true in the US before the opioid crisis.
> It causes problems because people are addicted to opioid drugs that are typically combined with acetaminophen,
- "Liver toxicity from acetaminophen poisoning is by far the most common cause of acute liver failure in the United States, researchers reported" [1] in 2005. It was also true before the opioid epidemic really began.
- "The recommended dose of acetaminophen in adults is 650 to 1,000 mg every 4 to 6 hours, not to exceed 4,000 mg in a 24-hour period." [2]
- "Single doses of more than 150 mg/kg or 7.5 g in adults have been considered potentially toxic." [2]
- "The minimal dose associated with liver injury can range anywhere from 4 to 10 g" [2]
The active dose is very close to the dose at which liver damage occurs (4X single dose or 1X daily dose) and also a fatal dose (10X single dose or 2.5X daily dose). Further, it's exacerbated by alcohol use, which is why you should never drink and then take Tylenol.
Wheres, ibuprofen the safety margin is 120X a single dose and 40X a daily dose. For naproxen, it's 63X a single dose or 21X a daily dose [3].
Windy has cool graphics, but it's only forecasted winds and not very granular. If you want to see actual wind observations from satellites check out ASCAT here[0] or here[1]
Sea level rise has regional variation due to the gravitational pull of the melting ice. When polar ice melts, there is less gravity at the poles so equatorial regions see higher sea level rise.
True. Unfortunately the quote does not mention gravity or melting ice at all. The two sentences are about the ocean warming and the differences in sea-level depending on how warm the local ocean is. This is just wrong (99.9% sure, but would update my view with some strong evidence). With a PhD in Earth Science and a Bachelors in Geophysics I am just sad when wrong ideas get expressed as the truth from scientists.
This is nothing compared to the estimated $3.5 billion to redirect the tracks underground in San Diego. Coastal bluff failures are occurring within several feet of the tracks on a regular basis. I spend time at this beach and I don't know how this track will be viable in a couple years, with or without rising sea levels. Once it is deemed unsafe, San Diego will be completely cut off by rail.
Given HN's general policy of disallowing paywalled links maybe we should also consider disalling GDPR-walled links. Sure, proxies and VPN's exist but it's a PITA just to read an LATimes article.
And SD will still have the trolley from TJ at least.
Is there some sort of legalese question you can ask to learn if the body of water you're about to enter is classified as a lake? Like: "is this a pool?". Sounds like a pretty big hole in the safety laws!
"Clean" is definitely not a word I'd use to describe this finding:
“Although the N. fowleri was not detected in the Surf Resort, Lazy River, or the Royal Flush, the presence of fecal indicator organisms, high turbidity, low free chlorine levels, and other amoeba that occur along with N. fowleri indicate conditions favorable for N. fowleri growth”
They're being charitable in their interpretation of the CDC's findings, to say the least.
This looks a lot more sophisticated than currently operating satellite wind mapping, which uses radar deflection off water to estimate wind speed and direction. I hope they make data as easily available as noaa:
* Overcrowded hospitals is what leads to large jumps in fatality rates.
* It only lags the date of infection by about a week.
* It also isn't subject to external factors like availability of tests. (Though availability of hospital beds is a factor later on)