Yes, that can be a problem. Story from one of my professors who worked on instrumentation and telemetry for a defense lab. They built a data recorder for artillery shells. In the early "flight" tests, the recorders failed and nobody could figure out why. They worked before and after. Then someone realized the high acceleration bent some of the bond wires in the chips, causing them to touch and short. The fix was surprisingly simple: make sure all chips face top down.