I asked the developer of Podcast Addict about this and shared the article. This is their response verbatim:
"Hi,
I'm sorry but I don't understand your email. Of course every podcast app connects to 3rd party content to stream it and therefore hosting platforms and tracking services and ad services used by the podcasters will have access to your IP address.
Sorry but saying that a podcast app leaks your IP address is as stupid as saying that a web browser does. It's just a tool that connects to 3rd party content, so yes unless you're using a VPN the server you connect to will always have access to your IP address
The app doesn't have your location. As you can see it doesn't ask for location permission so the app doesn't have anything to share, but yes your IP will of course be public to any server you connect to
I think my question still makes sense because from what I gather, the AdSense(?) SDK will get more info from the phone than just the IP address - make/model of the phone, unique IDs etc. But for now I happily did an OPML migration to AntennaPod - smooth sailing so far.
Another interesting point from the study (full paper linked in a other comment) was the comparison of semaglutide to other GLP-1 agonists taken by patients, with the impact being significantly higher vs. those.
Obviously we need some more double blind studies dedicated to this class of drugs and Alzheimer's, but this informs the direction researchers and drug companies will likely map out.
TL;DR from the article:
The study found that patients prescribed semaglutide had a significantly lower risk for Alzheimer’s disease than those who had taken one of the seven other diabetes drugs. The results were consistent across gender, age and weight.
The biggest difference was seen when comparing patients who took semaglutide to those who took insulin: Semaglutide patients had a 70% lower risk of Alzheimer’s, the study found.
With the constant stream of positive news around GLP-1s, and ever-growing list of things they treat, we may all wind up on some dose with only the dose varying depending on what illness they're targeting.
> With the constant stream of positive news around GLP-1s, and ever-growing list of things they treat, we may all wind up on some dose with only the dose varying depending on what illness they're targeting.
So far, I haven't seen much evidence that GLP-1s have a positive effect on people who aren't overweight. And while I'll be the first to admit that the proportion of people who could benefit from these drugs is quite large, it's pretty far from everyone.
> So far, I haven't seen much evidence that GLP-1s have a positive effect on people who aren't overweight.
It is licensed, tested, and sold as a Type-2 Diabetes medication. Are you claiming it is ineffective for that purpose? Or if you're under the impression that no healthy weight T2 Diabetics exist, I have some news for you...
It is also being studied for: opioid addiction, alcoholism, Alzheimer's/Parkinson’s, Cardiovascular Disease, NASH, and PCOS.
"So far, I haven't seen evidence" may be more related to what you have read than what is available for you to read.
Don't dismiss the most important question -- does semaglutide really have any effects outside its current intended use for diabetes and weight loss?
In other words, would a thin, metabolically healthy person benefit from taking semaglutide?
So far, all of the wonderful benefits from taking the drug seem to be explainable by reduced caloric intake / weight loss / better glucose control in overweight and/or diabetic people.
> In other words, would a thin, metabolically healthy person benefit from taking semaglutide?
That's what this thread is about; and multiple other studies looking at different diseases/illnesses/addictions. Time will tell. It is currently approved for T2 Diabetes and Obesity.
There's also the intriguing possibility that many other diseases and even addictions have a heretofore-unknown metabolic component. The idea of some addictions -- even to things like heroin or gambling -- being partially metabolic does not seem far-fetched to me.
GLP-1 have already been on the mass market longer than Fen-Phen (7-years for Fen-Phen Vs. 15+ years, even just Semaglutide has been available longer than Fen-Phen now, and Semaglutide is a third-gen GLP-1).
Honestly, this retort can be made about any/all new drugs entering the market. If you had a legitimate retort/critique I'm sure you would have presented it, but this is all we get.
This is what happens when you start out with "[thing] is bad" then work backwards to figure out a reason.
Ultimately the main reason it's bad right now is it's expensive. Far beyond the amount needed to recoup research investment and far far far far far far far far far beyond what it takes to synthesize.
Low-end cost of $1000 a month is a lot. That's an expensive car lease, or half a cheap mortgage.
Suddenly USGov issues emergency production licenses and orders domestically to drop that down to effectively $0.10/kilodose on the market.
Suddenly when Denmark (or whoever) whines, USGov sends a cumulative NATO military defense bill, tells them they are the reserve currency, they have bigger nukes, and tough shit next time don't pork barrel the American people.
Lots of options for Americans; question is, can we be unprincipled enough to take the steps neccessary? :^)
I fully agree. Least of all because it is sold at between $60-200 abroad full-priced. Those countries just have price controls; the pharmacies are still making 80%+ profit margins in those places.
Ultimately, a lot of people will literally die because of this greed. That isn't hyperbole.
I mean it's literally as if people don't understand how drugs work, or what drugs actually do to human bodies.
It is as if those who do not remember the past are repeating it, already.
So many shills are singing the praises of this wonder drug.
In India we're all the rave
Discovered that it's great as aftershave, oh-ho
Dropped in the sea just off Japan
Swapped twenty bottles for an aqua-walkman, oh
Immunity from ridicule
Improves your brains if you're a fool, oh-ho
And I read in the Middle East
Traded some for a hostage release
Now if you're bald it'll give you hair
If you've got straight trousers it'll give you flares
Feeling up you'll get depressed
Out of style here's a brand new dress, oh
It was really vile weather
When we got tarred and feathered
You could hear the six-guns sound
As they chased us out of town
Worth noting that 23andMe, plus many other low cost genealogy/health-focused companies do not sequence your DNA.
Instead, they perform what is called a genotyping microarray test, which looks at less than 0.1% of your genome.
To quote from 23andMe:
"In order to be genotyped, the amplified DNA is “cut” into smaller pieces, which are then applied to our DNA chip (also known as a microarray), a small glass slide with millions of microscopic “beads” on its surface. Each bead is attached to a “probe," a bit of DNA that matches one of the genetic variants that we test. The cut pieces of your DNA stick to the matching DNA probes. A fluorescent label on each probe identifies which version of that genetic variant your DNA corresponds to."
This post was submitted with the following title from the original article per the guidelines:
"In gold-standard trial, colonoscopy fails to reduce rate of cancer deaths"
One thing to consider if you have any foreign employees you sponsor on temporary working visas (think H1B, E3, etc.) to work in the US: Oftentimes these folks will have extremely limited time to get their affairs in order and leave the country if they can't find another job.
One thing you can do, that costs you nothing, is give them the option to instead continue to work out their 2 months in lieu of severance to provide an extra 60 days of job search.
Quite often they'll have a family, home, car and assets in the US that they'll need to deal with if they can't secure another job in that limited window.
Yeah, to me this is the difficult one - someone on a temporary working visa. Unlike people who don't require visas and can can immediately start looking for work, (I understand) visas require sponsorship. This, in turn, can cause huge family and financial hardships since their lives will be uprooted as they return back to their country. Imagine one of your visa workers just bought a home two months ago and now must leave the country.
I don't know the visa working rules very well. Does anyone know how long a visa worker can reside in country while looking for another job/sponsorship?
As the other poster said, it's a special type of collateralized loan where since everything is known, it can be done automatically.
You can get approved for a margin account at TD Ameritrade right now, and then later decide to margin some shares for whatever reason. The bank doesn't need to check your collateral because it knows how much it is worth at any given moment when the market is open.
Mortgage loans are not nearly as formalized, and the bank will send out an appraiser to verify that the property is worth an amount that they're willing to loan against.
And once you get past that, it becomes very hand-wavy; banks making loans to governments, non-profits, private companies, etc will all have their internal departments that make decisions about how much the risk is and what premium they'd need to charge.
A margin loan is just a loan where securities are the collateral asset.
The major feature of a margin loan versus other types of loans collateralized by assets is that the value of the underlying security (collateral) is tracked and depending on the terms of the margin loan, the lender has the right to issue a "margin call" demanding additional collateral or cash if the underlying securities have declined in value. These rules, called "house requirements," vary from lender to lender.
Margin loans use commonly traded commodities, normally stocks. Because they are easy to value (compared to a house) and liquid they are easier to get. However, because they are easy to value, they get compared to the loan value constantly. You'll be allowed to borrow X% of the values of your shares. If they go up, you can borrow more money. If they go down, you have to immediately pay off part of that loan. Since X < 100%, you can do so by selling shares (but of course, that decreases the amount of the collateral you have again), but you could also just deposit cash or pay it another way. They normally are more than happy for you to not have to sell shares if you deposit money.
Ok that makes sense, but I thought his other loan from MS was also using his stock as collateral?
If you're MS, why would you want to treat stock as "normal" collateral instead of using a margin loan? Is that Elon only feels comfortable using so much of his stock for a margin loan, and wants to use the rest as "normal" collateral (but is then getting less favorable terms for it)?
I have no idea why MS would choose to mix-and-match. Maybe the margin department has a global limit and that's hit by giving most of it to Musk? Maybe the margin department only covers the amount of Musk's stock they think they can sell in a margin call without causing the stock to tank? Maybe the other loan was using SpaceX stock (margin would only apply to public stock)?
It's also possible that Elon is getting a lower rate for the non-margin loan, but at a much worse multiple (putting up far more shares as collateral).
"Hi,
I'm sorry but I don't understand your email. Of course every podcast app connects to 3rd party content to stream it and therefore hosting platforms and tracking services and ad services used by the podcasters will have access to your IP address. Sorry but saying that a podcast app leaks your IP address is as stupid as saying that a web browser does. It's just a tool that connects to 3rd party content, so yes unless you're using a VPN the server you connect to will always have access to your IP address The app doesn't have your location. As you can see it doesn't ask for location permission so the app doesn't have anything to share, but yes your IP will of course be public to any server you connect to
Xavier"