That describes a related but previous Nature paper from the same group, whereas this is referring to a more recent Science paper.

Yeah seems like related to homeopathic medicine (aromatherapy or essential oils or tinctures)

the study said that the 5 patients with VITT that they looked at had the IGLV3-21 * 02 polymorphism, but it's a fallacy to say that means that you can't get clotting without it

that study used TALENs; this one used CRISPR base editors

It's a shame that Perceptive Automata shut down.

Glp and G9a are ubiquitous as they are import epigenetic regulators (histone methyltransferases). Sounds difficult to work on, and hard to supplement if they play an important role in many cell types

Yes, it turns out GLP is a very important protein. The second paper I cited above makes it sound it is pretty easy to supplement mice with GLP.

TRP channels were first cloned over 20 years ago, and are indeed medically relevant for nociception and pain. The piezos are equally relevant; knockouts are embryonically lethal, and the function of mechanosenstation in somatosenation and in general continue to be elucidated. For instance, it was only a few years that they were identified as being required for the baroreceptor reflex.

As an example, Douglas Bates, the author of R's lme4 excellent package for generalized linear mixed-effects models, has switched to julia to develop MixedModels.jl. The julia version is already excellent, and has many improvements over lme4.

David Baker's group (author of the RoseTTAFold paper out today in science) has multiple exciting examples of de novo design of proteins.

For example, see [1] or [2], and [2] was spun off into a company (Neoleukin Therapeutics).

[1] https://science.sciencemag.org/content/371/6531/eabc8182 [2] https://www.nature.com/articles/s41586-018-0830-7

This paper is the first structure of any odorant receptor-ligand interaction. There's currently no equivalent structure for mammalian odorant receptors to validate the docking theory, but it's likely correct.